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Toxicon. 2017 Oct;137:54-57. doi: 10.1016/j.toxicon.2017.07.014. Epub 2017 Jul 15.

Earwax: A clue to discover fluoroacetate intoxication in cattle.

Author information

1
Universidade Federal de Goiás (UFG), Campus Samambaia, Instituto de Química (IQ) - Laboratório de Métodos de Extração e Separação (LAMES), CEP: 74690-900, Goiânia, GO, Brazil. Electronic address: angeliqa26582@yahoo.com.
2
Instituto Federal Goiano - Campus Urutaí, Rod. Geraldo Silva Nascimento, km 2,5 Zona Rural, CEP 7579-000, Urutaí, GO, Brazil.
3
Escola de Veterinária e Zootecnia, Universidade Federal de Goiás (UFG), Rodovia Goiânia - Nova Veneza, km 8 Campus Samambaia, CEP 74001-970, Goiânia, GO, Brazil.
4
Universidade Federal de Goiás (UFG), Campus Samambaia, Instituto de Química (IQ) - Laboratório de Métodos de Extração e Separação (LAMES), CEP: 74690-900, Goiânia, GO, Brazil.

Abstract

An innovative method was developed to detect fluoroacetate poisoning in cattle by headspace/gas chromatographic analysis of earwax samples of intoxicated cattle. Samples were collected from 2 groups of cattle subjected to induced fluoroacetate intoxication, each group receiving a different dose of acetamide (antidote). Monofluoroacetic acid was detected in samples of intoxicated cattle in concentrations inversely proportional to the dose of acetamide. Thus, earwax analysis represents a successful approach for detection and monitoring of fluoroacetate poisoning.

KEYWORDS:

Bovine; Compound 1080; Earwax; Fluoroacetate poisoning; HS/GC-MS

PMID:
28716647
DOI:
10.1016/j.toxicon.2017.07.014
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