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Urol Clin North Am. 2017 Aug;44(3):491-505. doi: 10.1016/j.ucl.2017.04.014.

New Frontiers of Basic Science Research in Neurogenic Lower Urinary Tract Dysfunction.

Author information

1
Department of Urology, Graduate School of Medicine, University of the Ryukyus, Okinawa 903-0215, Japan; Department of Urology, University of Pittsburgh School of Medicine, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA.
2
Department of Urology, University of Pittsburgh School of Medicine, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA.
3
Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15216, USA.
4
Department of Medicine, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15216, USA.
5
Department of Urology, Graduate School of Medicine, University of the Ryukyus, Okinawa 903-0215, Japan.
6
Department of Urology, University of Pittsburgh School of Medicine, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15216, USA. Electronic address: nyos@pitt.edu.

Abstract

The lower urinary tract's main functions are storage and elimination. The micturition reflex pathway is modulated by the spinobulbospinal reflex pathway as well as higher brain centers involved in the voluntary micturition control. Micturition is sensitive to numerous injuries, resulting in various types of dysfunction. Animal studies indicate that lower urinary tract dysfunction partly depends on plasticity of the neural pathways. Reflex plasticity is associated with changes in ion channels, receptors, and numerous mediators. Animal models may aid in understanding the mechanisms leading to pathologic conditions and the plasticity in reflex pathways to the lower urinary tract after neurogenic lesions.

KEYWORDS:

Afferents; Animal model; Central nervous system; Lower urinary tract

PMID:
28716328
PMCID:
PMC5647782
DOI:
10.1016/j.ucl.2017.04.014
[Indexed for MEDLINE]
Free PMC Article

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