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Annu Rev Nutr. 2017 Aug 21;37:247-268. doi: 10.1146/annurev-nutr-071816-064620. Epub 2017 Jul 17.

FGF23 and Nutritional Metabolism.

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Center for Translational Health and Metabolism, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611; email:
Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27703; email:


The discovery of fibroblast growth factor 23 (FGF23) has provided a more complete understanding of the regulation of phosphate and mineral homeostasis in health and in chronic kidney disease. It has also offered new insights into stratification of risk of cardiovascular events and death among patients with chronic kidney disease and the general population. In this review, we provide an overview of FGF23 biology and physiology, summarize clinical outcomes that have been associated with FGF23, discuss potential mechanisms for these observations and their public health implications, and explore clinical and population health interventions that aim to reduce FGF23 levels and improve public health.


cardiovascular disease; chronic kidney disease; fibroblast growth factor 23; nutritional metabolism; phosphate

[Indexed for MEDLINE]

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