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Nat Prod Res. 2018 Jun;32(12):1390-1394. doi: 10.1080/14786419.2017.1350666. Epub 2017 Jul 17.

Acetyl- and O-alkyl- derivatives of β-mangostin from Garcinia mangostana and their anti-inflammatory activities.

Author information

1
a Faculty of Science, Department of Chemistry , Universiti Putra Malaysia , Serdang , Malaysia.
2
b Laboratory of Natural Products, Institute of Biosience , Universiti Putra Malaysia , Serdang , Malaysia.

Abstract

Pure β-mangostin (1) was isolated from the stem bark of Garcinia mangostana L. One monoacetate (2) and five O-alkylated β-mangostin derivatives (3-7) were synthesised from β-mangostin. The structures of these compounds were elucidated and determined using spectroscopic techniques such as 1D NMR and MS. The cytotoxicities and anti-inflammatory activities of these five compounds against RAW cell 264.7 were tested. The structural-activity relationship studies indicated that β-mangostin showed a significant activity against the LPS-induced RAW cell 264.7, while the acetyl- as well as the O-alkyl- β-mangostin derivatives did not give good activity. Naturally occurring β-mangostin demonstrated comparatively better anti-inflammatory activity than its synthetic counterparts.

KEYWORDS:

Acetyl- and O-alkyl- β-mangostin; anti-inflammation; β-mangostin

PMID:
28715912
DOI:
10.1080/14786419.2017.1350666
[Indexed for MEDLINE]

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