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Appl Physiol Nutr Metab. 2017 Nov;42(11):1228-1231. doi: 10.1139/apnm-2017-0182. Epub 2017 Jul 17.

Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice.

Author information

1
a Department of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada.
2
b Department of Nutrition, UNC Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599-7461, USA.
3
c UNC School of Medicine, University of North Carolina, Chapel Hill, NC 27516, USA.
4
d Nutrition Research Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 28081, USA.
5
e Department of Experimental Neurology, Center for Stroke Research Berlin, Charité University Medicine Berlin, Berlin 10117, Germany.

Abstract

Using a mouse model, this study examined the impact of lack of betaine homocysteine S-methyltransferase (BHMT) on neurological function. Bhmt-/- mice maintained on a control diet had elevated concentrations of homocysteine, reduced total brain magnetic resonance imaging (MRI) volume, as well as impaired reference and short-term memories. The results of this study indicate that the absence of BHMT may play a role in neurological function.

KEYWORDS:

IRM; MRI; Morris water maze; Y-maze; betaine homocysteine S-methyltransferase; bétaïne homocystéine S-méthyltransférase; homocysteine; homocystéine; labyrinthe aquatique de Morris; labyrinthe en Y; memory; mémoire

PMID:
28715642
DOI:
10.1139/apnm-2017-0182
[Indexed for MEDLINE]

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