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J Clin Invest. 2017 Sep 1;127(9):3201-3209. doi: 10.1172/JCI90602. Epub 2017 Jul 17.

Microglia in steady state.

Author information

1
Department of Life Sciences and MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom.
2
Institute of Neuropathology, Faculty of Medicine, University of Freiburg and BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany.

Abstract

Microglial cells are the resident tissue macrophages of the CNS and are widely recognized for their immune surveillance of the healthy CNS. In addition to this well-accepted function, recent findings point to major roles for microglia in instructing and regulating the proper function of the neuronal networks in the adult CNS, but these cells are also involved in creating neuronal networks by orchestrating construction of the whole network during development. In this Review, we highlight recent findings about the steady-state functions of microglial cells, the factors that are important for physiological microglial function, and how microglia help to maintain tissue homeostasis in the CNS.

PMID:
28714861
PMCID:
PMC5669563
DOI:
10.1172/JCI90602
[Indexed for MEDLINE]
Free PMC Article

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