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Magn Reson Med. 2017 Sep;78(3):1100-1109. doi: 10.1002/mrm.26820. Epub 2017 Jul 16.

Predicting IDH mutation status in grade II gliomas using amide proton transfer-weighted (APTw) MRI.

Author information

1
Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
2
Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
3
Department of Radiology, Futian Traditional Chinese Medicine Hospital, Shenzhen, Guangdong, China.
4
Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
5
Department of Pathology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
6
F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.

Abstract

PURPOSE:

To assess the amide proton transfer-weighted (APTw) MRI features of isocitrate dehydrogenase (IDH)-wildtype and IDH-mutant grade II gliomas and to test the hypothesis that the APTw signal is a surrogate imaging marker for identifying IDH mutation status preoperatively.

METHODS:

Twenty-seven patients with pathologically confirmed low-grade glioma, who were previously scanned at 3T, were retrospectively analyzed. The Mann-Whitney test was used to evaluate relationships between APTw intensities for IDH-mutant and IDH-wildtype groups, and receiver operator characteristic (ROC) analysis was used to assess the diagnostic performance of APTw.

RESULTS:

Based on histopathology and molecular analysis, seven cases were diagnosed as IDH-wildtype grade II gliomas and 20 cases as IDH-mutant grade II gliomas. The maximum and minimum APTw values, based on multiple regions of interest, as well as the whole-tumor histogram-based mean and 50th percentile APTw values, were significantly higher in the IDH-wildtype gliomas than in the IDH-mutant groups. This corresponded to the areas under the ROC curves of 0.89, 0.76, 0.75, and 0.75, respectively, for the prediction of the IDH mutation status.

CONCLUSION:

IDH-wildtype lesions typically were associated with relatively high APTw signal intensities as compared with IDH-mutant lesions. The APTw signal could be a valuable imaging biomarker by which to identify IDH1 mutation status in grade II gliomas. Magn Reson Med 78:1100-1109, 2017. © 2017 International Society for Magnetic Resonance in Medicine.

KEYWORDS:

CEST; IDH; amide proton transfer imaging-weighted; glioma; imaging biomarker

PMID:
28714279
PMCID:
PMC5561497
DOI:
10.1002/mrm.26820
[Indexed for MEDLINE]
Free PMC Article

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