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Neurobiol Sleep Circadian Rhythms. 2017 Jan;2:53-58. doi: 10.1016/j.nbscr.2016.11.001. Epub 2016 Nov 12.

Circadian Dysregulation in Parkinson's Disease.

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Movement Disorders Unit and Division of Sleep Medicine, Massachusetts General Hospital, Harvard Medical School, MGH Neurological Clinical Research Institute, 165 Cambridge Street, Suite 600, Boston, MA 02446, phone: 617.724.3837, fax: 617. 643.3558.
Department of Science and Technology, National University of Quilmes/CONICET, R.S. Peña 352, (1876) Bernal, Buenos Aires, Argentina, phone: +54-11-43657100 ext 5626, fax: +54-11-4365-7132.


Parkinson's disease (PD) is the second most common neurodegenerative disorder that affects over one million individuals in the US alone. PD is characterized by a plethora of motor and non-motor manifestations, resulting from a progressive degeneration of dopaminergic neurons and disbalance of several other neurotransmitters. A growing body of evidence points to significant alterations of the circadian system in PD. This is not surprising given the pivotal role that dopamine plays in circadian regulation as well as the role of circadian influences in dopamine metabolism. In this review we present basic and clinical investigations that examined the function of the circadian system in PD.


Parkinson’s; circadian; clock genes; dopamine; sleep

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