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Gynecol Obstet Fertil Senol. 2017 Jul - Aug;45(7-8):393-399. doi: 10.1016/j.gofs.2017.06.003. Epub 2017 Jul 13.

[Endometriosis and miscarriage: Systematic review].

[Article in French]

Author information

1
Maternité régionale universitaire, centre hospitalier universitaire de Nancy, rue Heydenreich, 54000 Nancy, France. Electronic address: helene2104@aol.com.
2
Maternité régionale universitaire, centre hospitalier universitaire de Nancy, rue Heydenreich, 54000 Nancy, France. Electronic address: anaisdesouz@gmail.com.
3
Maternité régionale universitaire, centre hospitalier universitaire de Nancy, rue Heydenreich, 54000 Nancy, France. Electronic address: C.mezandemalartic@chru-nancy.fr.
4
Maternité régionale universitaire, centre hospitalier universitaire de Nancy, rue Heydenreich, 54000 Nancy, France. Electronic address: m.agopiantz@chru-nancy.fr.
5
Maternité régionale universitaire, centre hospitalier universitaire de Nancy, rue Heydenreich, 54000 Nancy, France. Electronic address: F.guillet-may@chru-nancy.fr.
6
Maternité régionale universitaire, centre hospitalier universitaire de Nancy, rue Heydenreich, 54000 Nancy, France. Electronic address: olivier.morel17@gmail.com.
7
Maternité régionale universitaire, centre hospitalier universitaire de Nancy, rue Heydenreich, 54000 Nancy, France. Electronic address: ronancallec@yahoo.fr.

Abstract

OBJECTIVES:

In spontaneous pregnancies, endometriosis appears to be a risk factor of miscarriage. The aim of this study is to evaluate the association between endometriosis and miscarriage in spontaneous pregnancy.

METHODS:

We searched the Cochrane Library, Medline of eligible studies from inception to December 2016, without any restriction. We selected studies that compared endometriosis-affected pregnant women to disease-free pregnant women. To ensure the quality of the methodology, the PRISMA criteria have been met at all stages of the development of this meta-analysis. The primary adverse pregnancy outcomes studied was miscarriage. Three reviewers independently extracted the studies' characteristics and outcome data.

RESULTS:

Of 225 identified abstracts, 4 primary studies met our inclusion criteria by comparing spontaneous pregnant patients with endometriosis to disease-free women. Miscarriage rate was higher in the endometriosis group (OR 1.77 [CI 95% 1.13-2.78]).

CONCLUSION:

In spontaneous pregnancies, endometriosis appears to be a risk factor of miscarriages (almost 80% increased risk). Further prospective studies are needed to confirm these results in order to establish the exact impact of endometriosis on spontaneous pregnancy course.

KEYWORDS:

Avortement spontané; Endometriosis; Endométriose; Fausse couche spontanée; Fetal loss; Grossesse spontanée; Miscarriage; Perte fœtale; Spontaneous abortion; Spontaneous pregnancy

PMID:
28712793
DOI:
10.1016/j.gofs.2017.06.003
[Indexed for MEDLINE]

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