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Neuron. 2017 Aug 2;95(3):639-655.e10. doi: 10.1016/j.neuron.2017.06.028. Epub 2017 Jul 14.

Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican.

Author information

1
Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK; Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, Sant Joan d'Alacant 03550, Spain.
2
Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK.
3
Randall Division of Cell and Molecular Biophysics, King's College London, London, SE1 1UL, UK.
4
Clinical Neurosciences Department, King's College, NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.
5
MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK; MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.
6
Randall Division of Cell and Molecular Biophysics, King's College London, London, SE1 1UL, UK; Institute for Chemistry and Biochemistry, Free University Berlin, 14195 Berlin, Germany.
7
Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK; Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, Sant Joan d'Alacant 03550, Spain. Electronic address: beatriz.rico@kcl.ac.uk.

Abstract

Activity-dependent neuronal plasticity is a fundamental mechanism through which the nervous system adapts to sensory experience. Several lines of evidence suggest that parvalbumin (PV+) interneurons are essential in this process, but the molecular mechanisms underlying the influence of experience on interneuron plasticity remain poorly understood. Perineuronal nets (PNNs) enwrapping PV+ cells are long-standing candidates for playing such a role, yet their precise contribution has remained elusive. We show that the PNN protein Brevican is a critical regulator of interneuron plasticity. We find that Brevican simultaneously controls cellular and synaptic forms of plasticity in PV+ cells by regulating the localization of potassium channels and AMPA receptors, respectively. By modulating Brevican levels, experience introduces precise molecular and cellular modifications in PV+ cells that are required for learning and memory. These findings uncover a molecular program through which a PNN protein facilitates appropriate behavioral responses to experience by dynamically gating PV+ interneuron function.

KEYWORDS:

AMPA receptors; Kv channels; Parvalbumin interneurons; activity-dependent; inhibitory circuitries; learning and memory; perineuronal nets; plasticity; synapse maturation

PMID:
28712654
DOI:
10.1016/j.neuron.2017.06.028
[Indexed for MEDLINE]
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