Format

Send to

Choose Destination
Radiat Oncol J. 2017 Jun;35(2):129-136. doi: 10.3857/roj.2017.00010. Epub 2017 Jun 30.

Effect of time interval between capecitabine intake and radiotherapy on local recurrence-free survival in preoperative chemoradiation for locally advanced rectal cancer.

Author information

1
Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
2
Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
3
Department of Medical Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
4
Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
5
Department of Radiation Oncology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea.

Abstract

PURPOSE:

The concentration of capecitabine peaks at 1-2 hours after administration. We therefore assumed that proper timing of capecitabine administration and radiotherapy would maximize radiosensitization and influence survival among patients with locally advanced rectal cancer.

MATERIALS AND METHODS:

We retrospectively reviewed 223 patients with locally advanced rectal cancer who underwent preoperative chemoradiation, followed by surgery from January 2002 to May 2006. All patients underwent pelvic radiotherapy (50 Gy/25 fractions) and received capecitabine twice daily at 12-hour intervals (1,650 mg/m2/day). Patients were divided into two groups according to the time interval between capecitabine intake and radiotherapy. Patients who took capecitabine 1 hour before radiotherapy were classified as Group A (n = 109); all others were classified as Group B (n = 114).

RESULTS:

The median follow-up period was 72 months (range, 7 to 149 months). Although Group A had a significantly higher rate of good responses (44% vs. 25%; p = 0.005), the 5-year local recurrence-free survival rates of 93% in Group A and 97% in Group B did not differ significantly (p = 0.519). The 5-year disease-free survival and overall survival rates were also comparable between the groups.

CONCLUSIONS:

Despite the better pathological response in Group A, the time interval between capecitabine and radiotherapy administration did not have a significant effect on survivals. Further evaluations are needed to clarify the interaction of these treatment modalities.

KEYWORDS:

Capecitabine; Chemoradiotherapy; Rectal neoplasms; Survival analysis

Supplemental Content

Full text links

Icon for Publishing M2Community Icon for PubMed Central
Loading ...
Support Center