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Microb Pathog. 2017 Sep;110:359-364. doi: 10.1016/j.micpath.2017.07.022. Epub 2017 Jul 12.

Virulent and pathogenic features on the Cronobacter sakazakii polymyxin resistant pmr mutant strain s-3.

Author information

1
School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
2
Department of Laboratory Medicine, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
3
School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, Guangzhou, China.
4
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China. Electronic address: Yanyanli1123@hotmail.com.
5
School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, Guangzhou, China; Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA. Electronic address: zhenbo.xu@hotmail.com.

Abstract

Cronobacter sakazakii is a well-known opportunistic pathogen responsible for necrotizing enterocolitis, meningitis and septicaemia in the premature, immunocompromised infants and neonates. This pathogen possesses various virulence factors and regulatory systems, and pmrA/pmrB regulatory system has been identified in a variety of bacterial species. The current study aims to investigate role of pmrA gene in the pathogenicity and virulence characteristics of Cronobacter sakazakii using whole genome sequencing and RNA-seq. Results demonstrated that the absence of pmrA has the potential to affect Cronobacter sakazakii on its pathogenicity, virulence and resistance abilities by regulating expression of numerous related genes, including CusB, CusC, CusR and ESA_pESA3p05434.

KEYWORDS:

Cronobacter sakazakii s-3; RNA-seq; Whole genome sequencing; pmrA gene

PMID:
28711508
DOI:
10.1016/j.micpath.2017.07.022
[Indexed for MEDLINE]

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