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Drug Discov Today. 2017 Oct;22(10):1582-1592. doi: 10.1016/j.drudis.2017.07.001. Epub 2017 Jul 12.

Curcumin and its topical formulations for wound healing applications.

Author information

1
Institute of Life Sciences, Nalco Square, Bhubaneswar, Orissa 751023, India.
2
Institute of Life Sciences, Nalco Square, Bhubaneswar, Orissa 751023, India. Electronic address: sanjeebsahoo2005@gmail.com.

Abstract

Oxidative damage and inflammation have been identified, through clinical and preclinical studies, as the main causes of nonhealing chronic wounds. Reduction of persistent chronic inflammation by application of antioxidant and anti-inflammatory agents such as curcumin has been well studied. However, low aqueous solubility, poor tissue absorption, rapid metabolism and short plasma half-life have made curcumin unsuitable for systemic administration for better wound healing. Recently, various topical formulations of curcumin such as films, fibers, emulsion, hydrogels and different nanoformulations have been developed for targeted delivery of curcumin at wounded sites. In this review, we summarize and discuss different topical formulations of curcumin with emphasis on their wound-healing properties in animal models.

PMID:
28711364
DOI:
10.1016/j.drudis.2017.07.001
[Indexed for MEDLINE]

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