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Rheum Dis Clin North Am. 2017 Aug;43(3):489-502. doi: 10.1016/j.rdc.2017.04.013.

A Review of Systemic Corticosteroid Use in Pregnancy and the Risk of Select Pregnancy and Birth Outcomes.

Author information

1
Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, Mail Code 0828, La Jolla, CA 92093-0412, USA. Electronic address: gbandoli@ucsd.edu.
2
Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, Mail Code 0828, La Jolla, CA 92093-0412, USA.
3
Department of Rheumatology, University of California, San Diego, 9500 Gilman Drive, Mail Code 0656, La Jolla, CA 92093-0412, USA.

Abstract

The evidence to date regarding corticosteroid exposure in pregnancy and select pregnancy and birth outcomes is limited and inconsistent. The authors provide a narrative review of published literature summarizing the findings for oral clefts, preterm birth, birth weight, preeclampsia, and gestational diabetes mellitus. Whenever possible, the results are limited to oral or systemic administration with a further focus on use in autoimmune disease. Although previous studies of corticosteroid exposure in pregnancy reported an increased risk of oral clefts in the offspring, more recent studies have not replicated these findings.

KEYWORDS:

Adverse pregnancy and birth outcomes; Corticosteroids; Pregnancy; Review

PMID:
28711148
PMCID:
PMC5604866
DOI:
10.1016/j.rdc.2017.04.013
[Indexed for MEDLINE]
Free PMC Article

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