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Brain Imaging Behav. 2019 Feb;13(1):180-188. doi: 10.1007/s11682-017-9751-6.

Parkinson's disease with mild cognitive impairment: severe cortical thinning antedates dementia.

Author information

1
Neurosciences Area, CIMA, Department of Neurology and Neurosurgery, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain.
2
Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
3
Centro integral en Neurociencias A.C. (CINAC), HM Hospitales Puerta del Sur, CEU San Pablo University, Madrid, Spain.
4
ICM - Institut du Cerveau et de la Moelle épinière, CENIR, Centre de NeuroImagerie de Recherche, Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris, 06 UMR, S 1127, Paris, France.
5
Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Madrid, Spain.
6
Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
7
Servicio de Neurología, Complejo Hospitalario de Navarra, Pamplona, Spain.
8
Neurosciences Area, CIMA, Department of Neurology and Neurosurgery, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain. maria.rodriguezoroz@biodonostia.org.
9
Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. maria.rodriguezoroz@biodonostia.org.
10
Department of Neurology, University Hospital Donostia, Neuroscience Unit BioDonostia Research Institute, 20014, San Sebastian, Spain. maria.rodriguezoroz@biodonostia.org.
11
Ikerbasque, Basque Foundation for Science, Bilbao, Spain. maria.rodriguezoroz@biodonostia.org.

Abstract

Mild cognitive impairment (MCI) in Parkinson's disease (PD) is a risk factor for dementia and thus, it is of interest to elucidate if specific patterns of atrophy in PD-MCI patients are associated with a higher risk of developing dementia. We aim to define pattern(s) of regional atrophy in PD-MCI patients who developed dementia during 31 months of follow-up using cortical thickness analysis Twenty-three PD-MCI patients and 18 controls underwent brain MRI and completed a neuropsychological examination at baseline, PD-MCI patients were followed after a 31 month follow-up in order to assess their progression to dementia. At follow up, 8 PD-MCI patients had converted to dementia (PD-MCI converters) whereas 15 remained as PD-MCI (PD-MCI non-converters). All patients were at least 60 years old and suffered PD ≥ 10 years. There were no baseline differences between the two groups of patients in clinical and neuropsychological variables. The cortex of PD-MCI converters was thinner than that of PD-MCI non-converters, bilaterally in the frontal, insula and the left middle temporal areas, also displaying a more widespread pattern of cortical thinning relative to the controls. This study shows that aged and long-term PD patients with MCI who convert to dementia in the short-mid term suffer a thinning of the cortex in several areas (frontal cortex, and middle temporal lobe and insula), even when their cognitive impairment was similar to that of PD-MCI non-converters. Thus, MRI analysis of cortical thickness may represent a useful measure to identify PD-MCI patients at a higher risk of developing dementia.

KEYWORDS:

Cortical thickness; Dementia; Mild cognitive impairment; Parkinson’s disease

PMID:
28710667
DOI:
10.1007/s11682-017-9751-6
[Indexed for MEDLINE]

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