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Biochem Soc Trans. 2017 Aug 15;45(4):1007-14. doi: 10.1042/BST20160364. Epub 2017 Jul 14.

Post-transcriptional control of gene expression following stress: the role of RNA-binding proteins.

Author information

1
Medical Research Council Toxicology Unit, Lancaster Rd, Leicester LE1 9HN, U.K.
2
Medical Research Council Toxicology Unit, Lancaster Rd, Leicester LE1 9HN, U.K. mp540@le.ac.uk aew5@le.ac.uk.

Abstract

The ability of mammalian cells to modulate global protein synthesis in response to cellular stress is essential for cell survival. While control of protein synthesis is mediated by the regulation of eukaryotic initiation and elongation factors, RNA-binding proteins (RBPs) provide a crucial additional layer to post-transcriptional regulation. RBPs bind specific RNA through conserved RNA-binding domains and ensure that the information contained within the genome and transcribed in the form of RNA is exported to the cytoplasm, chemically modified, and translated prior to folding into a functional protein. Thus, this group of proteins, through mediating translational reprogramming, spatial reorganisation, and chemical modification of RNA molecules, have a major influence on the robust cellular response to external stress and toxic injury.

KEYWORDS:

RNA-binding proteins; epitranscriptome; stress granules; stress response; translation; translational reprogramming

PMID:
28710288
PMCID:
PMC5655797
DOI:
10.1042/BST20160364
[Indexed for MEDLINE]
Free PMC Article

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