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Cell. 2017 Jul 13;170(2):393-406.e28. doi: 10.1016/j.cell.2017.06.032.

Mapping the Neural Substrates of Behavior.

Author information

1
Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
2
Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA; Laboratory of Integrative Brain Function, The Rockefeller University, New York, NY, USA.
3
Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA; Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA.
4
Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA; Department of Molecular, Cellular, and Developmental Biology, UC Santa Barbara, Santa Barbara, CA, USA.
5
Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA. Electronic address: bransonk@janelia.hhmi.org.

Abstract

Assigning behavioral functions to neural structures has long been a central goal in neuroscience and is a necessary first step toward a circuit-level understanding of how the brain generates behavior. Here, we map the neural substrates of locomotion and social behaviors for Drosophila melanogaster using automated machine-vision and machine-learning techniques. From videos of 400,000 flies, we quantified the behavioral effects of activating 2,204 genetically targeted populations of neurons. We combined a novel quantification of anatomy with our behavioral analysis to create brain-behavior correlation maps, which are shared as browsable web pages and interactive software. Based on these maps, we generated hypotheses of regions of the brain causally related to sensory processing, locomotor control, courtship, aggression, and sleep. Our maps directly specify genetic tools to target these regions, which we used to identify a small population of neurons with a role in the control of walking.

KEYWORDS:

Drosophila; behavior; computer vision; machine learning; neural activation; neural anatomy; neural substrates; neuroscience; whole-brain mapping

PMID:
28709004
DOI:
10.1016/j.cell.2017.06.032
[Indexed for MEDLINE]
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