Send to

Choose Destination
Arch Physiol Biochem. 2018 Feb;124(1):27-34. doi: 10.1080/13813455.2017.1352606. Epub 2017 Jul 14.

Subchronic exposure to kalach 360 SL-induced endocrine disruption and ovary damage in female rats.

Author information

a Histology-Embryology Laboratory , Sfax Faculty of Medicine , Sfax , Tunisia.
b Biochemical Laboratory , Habib Bourguiba Hospital , Sfax , Tunisia.
c Pharmacology Laboratory , Sfax Faculty of Medicine , Sfax , Tunisia.


Kalach 360 SL (KL), glyphosate (G) surfactant-based herbicides, is a systemic herbicide effective against weeds. It was applied in agriculture in Tunisia and throughout the world, which can represent a risk to non-target organisms. The aim of this study was to investigate the morphological and biochemical aspects of ovary injury after exposure to KL. Female Wistar rats were divided into three groups: group 1 was used as a control; group 2 orally received 0.07 ml of KL, (126 mg of G/kg) and group 3 orally received 0.175 ml of KL (315 mg of G/kg) each day for 60 days. The subchronic exposure of KL induces impaired folliculogenesis, ovary development, decreased oestrogen secretion, promoted oxidative stress and impairments of ovary histological aspects. Histological finding shows necrosis cell, vacuolisation of follicles, dissociated oocytes and granulosa cell, associated with several atretic follicles. We conclude that KL induces endocrine disruption and ovary damage in female rats.


Kalach 360 SL; glyphosate; oestrogen; ovary injury; oxidative stress

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center