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Phytother Res. 2017 Sep;31(9):1316-1322. doi: 10.1002/ptr.5856. Epub 2017 Jul 14.

Efficacy of a Proprietary Trigonella foenum-graecum L. De-Husked Seed Extract in Reducing Menopausal Symptoms in Otherwise Healthy Women: A Double-Blind, Randomized, Placebo-Controlled Study.

Author information

1
Sydney Medical School, The University of Sydney, Sydney, Australia.
2
Institute of Health and Biomedical Innovation, School of Public Health, Queensland University of Technology, Brisbane, Australia.
3
Hospital Havelhöhe, Research Institute Havelhöhe, Berlin, Germany.
4
The BRIDI Centre Pty. Ltd, Brisbane, Australia.

Abstract

Trigonella foenum-graecum seed extract has demonstrated hormone modulatory activity, providing biological plausibility for relieving menopausal symptoms. The study aimed to assess efficacy of a standardized T. foenum-graecum de-husked seed extract in reducing menopausal symptoms in healthy aging women. The study was a double-blind, randomized, placebo-controlled trial that recruited 115 women aged 40 to 65 years of which 59 were allocated to active (n = 54 completed) and 56 to placebo (n = 50 completed). Active treatment was T. foenum-graecum de-husked seed extract, 600 mg per day for 12 weeks. Outcome measures included Menopause-Specific Quality of Life (MENQOL) questionnaire, frequency of hot flushes and night sweats and serum estradiol levels. There was a significant reduction in menopausal symptoms in the active group compared with placebo as assessed by total MENQOL score (p < 0.001); reflected by significant improvements in the vasomotor (p < 0.001), psychosocial (p < 0.001), physical (p < 0.001) and sexual symptoms (p < 0.001) domains. Vasomotor outcomes correlated with hot flushes, the active group reporting significantly less daytime hot flushes and night sweats at 12 weeks (p < 0.001). The average estradiol levels were similar in both the active group and placebo group after treatment. This study demonstrated that this proprietary T. foenum-graecum de-husked seed extract may reduce menopausal symptoms in healthy women.

KEYWORDS:

Trigonella foenum-graecum; fenugreek; hot flushes; menopause; night sweats

PMID:
28707431
DOI:
10.1002/ptr.5856
[Indexed for MEDLINE]

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