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J Pharmacol Pharmacother. 2017 Apr-Jun;8(2):50-53. doi: 10.4103/jpp.JPP_156_16.

Efficacy of Atorvastatin in Prevention of Contrast-induced Nephropathy in High-risk Patients Undergoing Angiography: A Double-blind Randomized Controlled Trial.

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Department of Pharmacology, Indian Institute of Medical Science and Research and Noor Hospital, Jalna, Maharashtra, India.
Department of Pharmacology, Government Medical College and Hospital, Aurangabad, Maharashtra, India.
Department of Pharmacology, People's College of Medical Sciences and Research Centre, Bhopal, Maharashtra, India.
Department of Pharmacology, Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospital, Pune, Maharashtra, India.



To evaluate the efficacy and safety of atorvastatin (ATN) 80 mg in the prevention of contrast medium- induced nephropathy (CIN) in high risk patients undergoing angiograph.


This was a prospective, double-blind, two-arm, parallel group RCT. A total of 216 patients undergoing coronary angiography were screened, and 188 eligible patients were randomized to two treatment arms. Patients in Group A received tablet N-acetylcysteine (NAC) 1200 mg once daily, and patients in Group B received tablet atorvastatin 80 mg + NAC 1200 mg once daily, for 3 days before, and 2 days after angiography.


A total of 160 patients completed the trial. Postprocedure, nine and two CIN cases were found in Group A and B, respectively. The mean change in serum creatinine was 0.086 ± 0.168 in Group A and 0.021 ± 0.083 in Group B, which was statistically significant (P = 0.0289). Postprocedure, the estimated glomerular filteration rate was reduced by 19.52 in Group A and 13.55 in Group B (P = 0.003).


This trial indicates the positive role of statins in preventive strategy against CIN along with NAC.


Atorvastatin; N-acetylcysteine; contrast-induced nephropathy

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