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Nanomedicine (Lond). 2017 Aug;12(15):1801-1822. doi: 10.2217/nnm-2017-0080. Epub 2017 Jul 14.

Biodistribution and clearance of magnetoelectric nanoparticles for nanomedical applications using energy dispersive spectroscopy.

Author information

1
Department of Electrical & Computer Engineering, Florida International University, Miami, FL, USA.
2
Center for Hardware Assurance, Security, & Engineering, University of Connecticut, Storrs, CT, USA.
3
Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
4
Cellular Nanomed, Inc., Irvine, CA, USA.

Abstract

AIM:

The biodistribution and clearance of magnetoelectric nanoparticles (MENs) in a mouse model was studied through electron energy dispersive spectroscopy.

MATERIALS & METHODS:

This approach allows for detection of nanoparticles (NPs) in tissues with the spatial resolution of scanning electron microscopy, does not require any tissue-sensitive staining and is not limited to MENs.

RESULTS:

The size-dependent biodistribution of intravenously administrated MENs was measured in vital organs such as the kidneys, liver, spleen, lungs and brain at four different postinjection times including 1 day, 1 week, 4 and 8 weeks, respectively.

CONCLUSION:

The smallest NPs, 10-nm MENs, were cleared relatively rapidly and uniformly across the organs, while the clearance of the larger NPs, 100- and 600-nm MENs, was highly nonlinear with time and nonuniform across the organs.

KEYWORDS:

biodistribution; clearance; magnetoelectric nanoparticles; multiferroic nanoparticles; nanomedicine

PMID:
28705034
PMCID:
PMC5551528
DOI:
10.2217/nnm-2017-0080
[Indexed for MEDLINE]
Free PMC Article

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