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Folia Med (Plovdiv). 2017 Jun 1;59(2):159-164. doi: 10.1515/folmed-2017-0021.

Association between Type 2 Diabetes, Obesity and Key Immunological Components of IgE-mediated Inflammation.

Author information

1
Department of Dermatology and Venereology, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria
2
Department of Microbiology and Immunology, Faculty of Pharmacy, Medical University of Plovdiv, Plovdiv, Bulgaria
3
Division of Immunological Assessment of PTSD, Technological Center for Emergency Medicine, Plovdiv, Bulgaria
4
Second Department of Internal Medicine, Endocrinology Section, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria
5
Second Department of Internal Medicine, Section of Occupational Diseases and Toxicology, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria

Abstract

BACKGROUND:

Changes in lifestyle and obesity in recent decades have brought about a dramatic increase in type 2 diabetes mellitus (DM2) and allergic diseases. Clinical and epidemiological studies associate obesity with epidemics of allergic diseases. The link between obesity and DM2 with immunological components of IgE-mediated allergic inflammation is not yet conclusively established.

AIM:

To examine the key immunological components of IgE-mediated allergic inflammation in patients with DM2 and their relationship with glycemic control and anthropometric indicators.

MATERIALS AND METHODS:

Fifty-five patients with DM2 and 32 healthy controls with normal weight and body mass index (BMI) of 18-24.9 kg/m2 were included in the study. Th2-cytokine profile (serum levels of IL-4 and IL-5, pg/ml) and total serum IgE IU/ml were assessed in all participants in the study using ELISA. In patients with DM2, levels of glycated hemoglobin (HbA1c%) in the blood were also measured.

RESULTS:

Serum levels of IL-4 and IL-5 are significantly higher in patients with DM2 compared to the control group. Serum levels of IL-4 and IL-5 positively correlated with BMI as well as serum levels of IL-4 with waist circumference. Total serum IgE positively correlated with HbA1c.

CONCLUSION:

Obesity and poor glycemic control in patients with DM2 affect key immunological components of IgE-mediated allergic inflammation and possibly alter the immune response to allergens and antigens.

KEYWORDS:

Th2 cytokines; type 2 diabetes

PMID:
28704195
DOI:
10.1515/folmed-2017-0021
[Indexed for MEDLINE]

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