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J Med Food. 2017 Aug;20(8):777-781. doi: 10.1089/jmf.2017.3928. Epub 2017 Jul 13.

Effect of Feeding High Gamma-Aminobutyric Acid-Containing Giant Embryo Black Sticky Rice (Oryza sativa L.) on Anxiety-Related Behavior of C57BL/6 Mice.

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1 Department of Psychiatry, Pusan National University Yangsan Hospital , Yangsan, Korea.
2 Department of Psychiatry, School of Medicine, Pusan National University , Yangsan, Korea.
3 Medical Research Institute, Pusan National University , Yangsan, Korea.
4 Department of Horticultural Bioscience, Pusan National University , Yangsan, Korea.
5 Department of Neuropsychiatry, College of Medicine, KyungHee University , Seoul, Korea.
6 Department of Neuropsychiatry, Yang-San Neuropsychiatric Hospital , Yangsan, Korea.


The aim of this study was to determine the effect of feeding high gamma-aminobutyric acid (GABA)-containing black sticky rice giant embryo (BSRGE, Oryza sativa L.) on anxiety-related behavior of C57BL/6 mice. Experimental feedstuff (BSRGE with high GABA+AIN-76A) and control (AIN-76A) were provided to C57BL/6 mouse for 10 days. Antianxiety effects of BSRGE with high GABA were measured using an elevated plus maze. On day 8, the number of open arm entries by GABA and control groups were 1.10 ± 1.60 (mean ± SD) and 0.00 ± 0.00 (P = .030). On day 10, the number of open arm entries by the GABA group was 2.00 ± 1.89, which was significantly (P = .025) higher than that in the control group (0.40 ± 0.84). On day 8, the time the mice spent in open arm in the GABA group and control group was 3.60 ± 7.06 and 0.00 ± 0.00 sec (P = .068), respectively. On day 10, the time the mice in the GABA and control groups spent in open arm was 6.20 ± 5.35 sec and 1.80 ± 3.82 sec (P = .042), respectively. In repeated analysis of variance for the number of entries into open arm and time spent in open arm, significant differences were found between the two groups. Therefore, BSRGE with high GABA content might have an antianxiety effect. This study can serve as a preliminary study so that further antianxiety effects of BSRGE can be determined in more extended animal or clinical research studies in the future.


C57BL/6 mice; GABA; anxiety; black sticky rice giant embryo; elevated plus maze

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