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J Am Chem Soc. 2017 Aug 2;139(30):10208-10211. doi: 10.1021/jacs.7b05327. Epub 2017 Jul 13.

Cobalt Catalysis for Enantioselective Cyclobutanone Construction.

Author information

1
Department of Chemistry, University of California, Irvine , Irvine, California 92697, United States.

Abstract

Over the past 40 years, intramolecular hydroacylation has favored five-membered rings, in preference to four membered rings. Herein, we report a catalyst derived from earth-abundant cobalt that enables preparation of cyclobutanones, with excellent regio-, diastereo-, and enantiocontrol, under mild conditions (2 mol % catalyst loading and as low as 50 °C).

PMID:
28704053
PMCID:
PMC6824591
DOI:
10.1021/jacs.7b05327
[Indexed for MEDLINE]
Free PMC Article

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