Format

Send to

Choose Destination
Brain Pathol. 2018 Jan;28(1):3-13. doi: 10.1111/bpa.12545. Epub 2017 Aug 6.

Autophagy in neurodegenerative diseases: pathogenesis and therapy.

Guo F1, Liu X2, Cai H3, Le W1,2,4.

Author information

1
The Key Laboratory of Stem Cell Biology and Neurogenomic Laboratory, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
2
Clinical Research Center on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian, 116011, China.
3
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD.
4
Collaborative Innovation Center for Brain Science, the First Affiliated Hospital, Dalian Medical University, Dalian, 116011, China.

Abstract

The most prevalent pathological features of many neurodegenerative diseases are the aggregation of misfolded proteins and the loss of certain neuronal populations. Autophagy, as major intracellular machinery for degrading aggregated proteins and damaged organelles, has been reported to be involved in the occurrence of pathological changes in many neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis. In this review, we summarize most recent research progress in this topic and provide a new perspective regarding autophagy regulation on the pathogenesis of neurodegenerative diseases. Finally, we discuss the signaling molecules in autophagy-related pathways as therapeutic targets for the treatment of these diseases.

KEYWORDS:

autophagy; neurodegenerative diseases; protein aggregation

PMID:
28703923
PMCID:
PMC5739982
DOI:
10.1111/bpa.12545
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center