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Commun Integr Biol. 2017 Mar 2;10(3):e1300215. doi: 10.1080/19420889.2017.1300215. eCollection 2017.

GABA signaling stimulates α-cell-mediated β-like cell neogenesis.

Author information

1
Université Côte d'Azur, CNRS, Inserm, iBV, Nice, France.
2
Max-Planck Institute for Biophysical Chemistry, Department of Molecular Developmental Biology, Göttingen, Germany.
3
Department of Clinical Neurophysiology, University of Göttingen, Göttingen, Germany.

Abstract

Diabetes is a chronic and progressing disease, the number of patients increasing exponentially, especially in industrialized countries. Regenerating lost insulin-producing cells would represent a promising therapeutic alternative for most diabetic patients. To this end, using the mouse as a model, we reported that GABA, a food supplement, could induce insulin-producing beta-like cell neogenesis offering an attractive and innovative approach for diabetes therapeutics.

KEYWORDS:

Arx; GABA; Pax4; diabetes; β-cell regeneration

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