Send to

Choose Destination
Commun Integr Biol. 2017 Mar 2;10(3):e1300215. doi: 10.1080/19420889.2017.1300215. eCollection 2017.

GABA signaling stimulates α-cell-mediated β-like cell neogenesis.

Author information

Université Côte d'Azur, CNRS, Inserm, iBV, Nice, France.
Max-Planck Institute for Biophysical Chemistry, Department of Molecular Developmental Biology, Göttingen, Germany.
Department of Clinical Neurophysiology, University of Göttingen, Göttingen, Germany.


Diabetes is a chronic and progressing disease, the number of patients increasing exponentially, especially in industrialized countries. Regenerating lost insulin-producing cells would represent a promising therapeutic alternative for most diabetic patients. To this end, using the mouse as a model, we reported that GABA, a food supplement, could induce insulin-producing beta-like cell neogenesis offering an attractive and innovative approach for diabetes therapeutics.


Arx; GABA; Pax4; diabetes; β-cell regeneration

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center