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Front Neurol. 2017 Jun 28;8:312. doi: 10.3389/fneur.2017.00312. eCollection 2017.

Cerebellar Dysfunction in Multiple Sclerosis.

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MS and Stem Cell Group, University of Bristol, Learning and Research, Southmead Hospital, Bristol, United Kingdom.


Multiple sclerosis (MS) commonly affects the cerebellum causing acute and chronic symptoms. Cerebellar signs contribute significantly to clinical disability, and symptoms such as tremor, ataxia, and dysarthria are particularly difficult to treat. Increasing knowledge concerning the pathophysiology of cerebellar disease in MS from human postmortem studies, experimental models, and clinical trials has raised the hope that cerebellar symptoms will be better treated in the future.


ataxia; cerebellar diseases; demyelinating diseases; multiple sclerosis; purkinje cells

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