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Curr Med Res Opin. 2017 Dec;33(12):2195-2200. doi: 10.1080/03007995.2017.1354829. Epub 2017 Aug 11.

Increased cancer risk in patients with periodontitis.

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a Department of Preventive Oncology , Hacettepe University Cancer Institute , Ankara , Turkey.
b Department of Internal Medicine , Hacettepe University Faculty of Medicine , Ankara , Turkey.
c Department of Periodontology , Hacettepe University Faculty of Dentistry , Ankara , Turkey.



Previous studies have noted a possible association between periodontal diseases and the risk of various cancers. We assessed cancer risk in a cohort of patients with moderate to severe periodontitis.


Patients diagnosed with moderate to severe periodontitis by a periodontist between 2001 and 2010 were identified from the hospital registry. Patients younger than 35 years of age or with a prior cancer diagnosis were excluded. The age- and gender-standardized incidence rates (SIR) were calculated by dividing the number of observed cases by the number of expected cases from Turkish National Cancer Registry 2013 data.


A total of 280 patients were included (median age 49.6, 54% female). Median follow-up was 12 years. Twenty-five new cancer cases were observed. Patients with periodontitis had 77% increased risk of cancer (SIR 1.77, 95% CI 1.17-2.58, p = .004). Women with periodontitis had significantly higher risk of breast cancer (SIR 2.40, 95% CI 0.88-5.33) and men with periodontitis had significantly higher risk of prostate cancer (SIR 3.75, 95% CI 0.95-10.21) and hematological cancers (SIR 6.97, 95% CI 1.77-18.98).


Although showing a causal association necessitates further investigation, our results support the idea that periodontitis might be associated with increased cancer risk, particularly with hematological, breast and prostate cancers.


Periodontitis; breast cancer; cancer risk; lymphoma; prostate cancer

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