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Eur J Hum Genet. 2017 Oct;25(10):1165-1169. doi: 10.1038/ejhg.2017.109. Epub 2017 Jul 12.

Co-inheritance of mutations associated with arrhythmogenic cardiomyopathy and hypertrophic cardiomyopathy.

Author information

1
Department of Biology, University of Padua, Padua, Italy.
2
Department of Cardiac, Thoracic, and Vascular Sciences, University of Padua, Padua, Italy.

Abstract

Arrhythmogenic cardiomyopathy (ACM) and hypertrophic cardiomyopathy (HCM) are genetically and phenotypically distinct disorders of the myocardium. Here we describe for the first time co-inheritance of mutations in genes associated with ACM or HCM in two families with recurrence of both cardiomyopathies. Among the double heterozygotes for mutations in desmoplakin (DSP) and myosin binding protein C (MYBPC3) genes identified in Family A, two were diagnosed with ACM and two with HCM. In Family B, one patient was identified to carry mutations in α-T-catenin (CTTNA3) and β-myosin (MYH7) genes, but he does not fulfill the current diagnostic criteria neither for ACM nor for HCM. Interestingly, the double heterozygotes showed a variable clinical expression of both cardiomyopathies and they do not exhibit a more severe phenotype than family members carrying only one of the two mutations.

PMID:
28699631
PMCID:
PMC5602010
[Available on 2018-10-01]
DOI:
10.1038/ejhg.2017.109
[Indexed for MEDLINE]

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