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Curr Med Chem. 2018;25(33):4084-4101. doi: 10.2174/0929867324666170711114336.

The Role of Oxidative Stress Modulators in Breast Cancer.

Author information

1
Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Ege University, 35100 Izmir, Turkey.
2
Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Katip Celebi University, Balatcik 35620 Cigli Izmir, Turkey.
3
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandogan 06100, Ankara, Turkey.
4
Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy.

Abstract

BACKGROUND:

Latest data from International Agency for Cancer Research shows that breast cancer is the leading cancer site in women and is the leading cause of death among female cancers. Induction of reactive oxygen species (ROS) and oxidative stress as a consequence of impaired balance between prooxidants and antioxidants are suggested to be involved in induction and progression of breast cancer. Cancer cells are found to exhibit higher levels of ROS compared to normal cells. However increased antioxidant defence which balances the oxidative status within the cancer cells suggests that high ROS levels may prevent tumorigenesis via various mechanisms. These contradictory roles of ROS and oxidative stress in breast cancer let scientists investigate potential oxidative stress modulators as anticancer strategies.

CONCLUSIONS:

In the present review we address the mechanisms of ROS production in breast cancer cells, the role of impaired oxidative status as well as the benefits of introducing oxidative stress modulators in therapeutic strategies in breast cancer. This review is focusing more on melatonin which we have been working on during the last decade. Our data, in accordance with the literature, suggest an important role for melatonin in breast cancer prevention and adjuvant therapy.

KEYWORDS:

Oxidative stress; breast cancer; melatonin; oxidative stress modulators; reactive oxygen species.

[Indexed for MEDLINE]

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