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J Genomics. 2017 Jul 2;5:75-76. doi: 10.7150/jgen.19673. eCollection 2017.

Complete Genome Sequence of Actinomadura Parvosata Subsp. Kistnae, A Rich Source of Novel Natural Product (Bio-)Chemistry.

Author information

1
Biosystems Chemistry, Department of Chemistry and Center for Integrated Protein Science Munich (CIPSM), Technical University of Munich, Lichtenbergstra├če 4, 85748 Garching, Germany.

Abstract

The soil dwelling actinomycete strain Actinomadura parvosata subsp. kistnae is the producer of the antiviral antibiotics kistamicin A and B. Genome sequencing and bioinformatic analysis revealed the presence of the kistamycin biosynthetic gene cluster responsible for the formation of these non-ribosomal peptides as well as an impressive number of yet uncharacterized biosynthetic pathways. This includes polyketide, ribosomal and non-ribosomal peptide and a large number of terpenoid biosynthetic loci encoding yet unknown natural products. The genomic data of this strain is thus a treasure trove for genome mining for novel functional metabolites and new biocatalysts.

KEYWORDS:

Actinomadura parvosata subsp. kistnae; Kistamicin.; whole-genome sequencing

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

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