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Nutrients. 2017 Jul 8;9(7). pii: E719. doi: 10.3390/nu9070719.

Acute Supplementation with High Dose Vitamin D3 Increases Serum Anti-Müllerian Hormone in Young Women.

Author information

1
Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand. NDennis@abacusbio.co.nz.
2
Department of Human Nutrition, Division of Sciences, University of Otago, Dunedin 9054, New Zealand. lisa.houghton@otago.ac.nz.
3
Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand. michael.pankhurst@otago.ac.nz.
4
Department of Human Nutrition, Division of Sciences, University of Otago, Dunedin 9054, New Zealand. michelle.harper@otago.ac.nz.
5
Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand. ian.mclennan@otago.ac.nz.

Abstract

Anti-Müllerian hormone (AMH) is a paracrine regulator of ovarian follicles. Vitamin D (Vit D) regulates AMH production in vitro, but its role as a regulator of ovarian AMH production is contentious. If Vit D influences ovarian AMH production, then an acute rise in Vit D level should lead to an acute rise in circulating AMH levels. This hypothesis was tested with a randomized double-blind design, with 18-25-year-old women recruited from the community. The study was conducted in early spring, when the marker of Vit D level (25-hydroxyvitamin D, 25(OH)D) tends to be at its nadir. The women consumed either an oral dose of 50,000 IU of Vit D3 (n = 27) or placebo (n = 22). The initial 25(OH)D ± SD value was 53.6 ± 23.3 nmol/L, with 42 of the 49 women having a value below 75 nmol/L, consistent with seasonal nadir. All women receiving Vit D3 treatment exhibited a robust increase in serum 25(OH)D within 1 day (15.8 ± 1.1 nmol/L (n = 27), p < 0.0001), with the increase sustained over the study week. Circulating levels of AMH in the women receiving Vit D3 progressively rose during the following week, with a mean increase of 12.9 ± 3.7% (n = 24, p = 0.001). The study supports the hypothesis that Vit D's positive effects on the fertility of woman may involve the regulation of ovarian AMH levels.

KEYWORDS:

25(OH)D; AMH; female reproduction; ovary

PMID:
28698476
PMCID:
PMC5537834
DOI:
10.3390/nu9070719
[Indexed for MEDLINE]
Free PMC Article

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