Format

Send to

Choose Destination
Respir Care. 2017 Oct;62(10):1307-1315. doi: 10.4187/respcare.05481. Epub 2017 Jul 11.

Risk Factors for Noninvasive Ventilation Failure in Critically Ill Subjects With Confirmed Influenza Infection.

Collaborators (450)

Cobo P, Martins J, Carbayo C, Robles-Musso E, Cárdenas A, Fierro J, Ocaña Fernández D, Sierra R, Huertos MJ, Pérez MLC, Pozo Laderas JC, Guerrero R, Robles JC, Echevarría León M, Bermejo Gómez A, Márquez E, Rodríguez-Carvajal M, Estella Á, Pomares J, Ballesteros JL, Moreno Romero O, Fernández Y, Lobato F, Prieto JF, Albofedo-Sánchez J, Martínez P, de la Torre MV, Nieto M, Camara Sola E, Díaz Castellanos MA, Sevilla Soler G, Ortiz Leyba C, Garnacho-Montero J, Hinojosa R, Fernández E, Loza A, León C, González López S, Arenzana A, Ocaña D, Navarrete I, Zaheri Beryanaki M, Sánchez I, Pérez Alé M, Poullet Brea AM, Machado Casas JF, Serón C, Luis Avellanas M, Lander A, Ramírez de Arellano SG, Marquina Lacueva MI, Luque P, Plumed Serrano E, Martín Lázaro JF, Sánchez Polo C, Gutiérrez Cia I, Jiménez Bartolomé B, López Nuñez C, González I, Tomás Marsilla JI, Jaques Andrés C, Gtiérrez Ibañes P, Araujo Aguilar P, Montón JM, Dorado Regil P, Iglesias L, Pascual González C, Quindós Fernández B, Martín Iglesias L, Viña Soria L, Yano Escudero R, Del Rosario Mtnez Revuelta M, Quiroga, García-Rodríguez Á, Martín Cuadrado M, Balán Mariño AL, Socias L, Ibánez P, Borges-Sa M, Socias A, Del Castillo A, Jordà Marcos R, Muñoz C, Bonell JM, Amestarán I, González López MA, Vilanova Pàmies C, Bonell Goytisolo JM, Morales Carbonero JA, Bonell Goytisolo JM, Morales Carbonero JA, Pérez Senoff R, López de Medrano MG, Ruiz-Santana S, Díaz JJ, Sánchez Ramírez C, Sisón M, Hernández D, Trujillo A, Regalado L, Rodríguez Fndez S, Lorente L, Cabrera Rivero J, Quintero MLM, Martín M, Martínez S, Cáceres JJ, Sanchez Palacio M, Marcos, Rodríguez DG, Ripoll Leria M, Suberviola B, Ugarte P, García-López F, Sánchez Iniesta R, Álvaro Alonso A, Padilla A, Martínez Palacios B, Gómez Grande ML, Martín Rodríguez MC, Adbel-Hadi Álvarez H, Ambros Checa A, Martín Hernández H, Albaya A, Silva Obregón A, Marian Crespo C, Armendariz Estrella C, Benito Puncel C, Quirós Oyargue E, Canabal A, Marina L, López de Toro I, Simón A, Añón JM, López Messa JB, López Pueyo MJ, Del Valle Sergio Ossa Echeverri OM, Ferreras Z, Ballesteros Herraez JC, Macias S, Berezo JÁ, Blanco Varela J, Blanco Schweizer P, González Salamanca A, Tamayo Lomas L, Ojeda Anzález A, Cicuéndez Avila R, Pérez G FJ, Álvarez Terrero A, Tena Ezpeleta F, Sala C, López O, Paez Z, García Á, Carriedo Ule D, Riesco Crespo M, Pino Rebolledo J, Hidalgo Andrés N, Carolina Caballero Zirena A, Román García B, Bautista López Messa J, Del Valle Ortiz M, Ossa Echeverri S, Catalán RM, Ferrer M, Torres A, Cilloniz C, Barbadillo Ansorregui S, Cabré L, Baeza I, Rovira A, Álvarez-Lerma F, Vázquez A, Nolla J, Fernández F, Ramón Cervelló J, Iglesia R, Mañéz R, Ballús J, Granada RM, Vallés J, Díaz E, Ortíz M, Guía C, Martín-Loeches I, Páez J, Almirall J, Balanzo X, Güell E, Yebenes JC, Rello J, Arnau E, Pérez M, Laborda C, Souto J, Lagunes L, Catalán I, Sirvent JM, López de Arbina N, Baró Serra A, Sánchez A, Cuenca SM, Badía M, Baseda-Garrido B, Valverdú-Vidal M, Barcenilla F, Palomar M, Nuvials X, Garrido Benedicto P, Roche Campo F, Esteban MF, Luna J, Masdeu Eixarch G, Pascual Diago A, Nava JM, de Molina JG, Trenado J, Ferrer R, Josic Z, Casanovas M, Gurri F, Rodríguez P, Rodríguez A, Claverias L, Trefler S, Bodí M, Magret M, Ferri C, Díaz RM, Mesalles E, Arméstar F, de Mendoza D, Lomas Fernández C, Berrade JJ, Bonet Saris A, Pechkova M, Mora Jiménez C, Picos Gil S, Juliá-Narváez J, Robles Marcos M, Farje Mallqui V, Santiago Triviño MA, Martínez García P, Fernández-Zapata A, Recio T, Arrascaeta A, García-Ramos MJ, Gallego E, Saiz Rodrigo E, Bueno F, Díaz M, Gil Pérez N, López Hormigo D, Diego Jiménez Delgado J, Frutos P, Rivera Pinna MJ, Cordero ML, Pastor JA, Álvarez-Rocha L, Ceniceros Barros A, Virgós Pedreira A, Vila D, Fernández González C, Blanco Pérez J, Ortiz Piquer M, Merayo E, López-Ciudad VJ, Cortes Cañones J, Vilaboy E, Villar Chao J, Cid López FS, Vidal Cortés P, Pérez Veloso MA, Saborido EM, Alemparte Pardavila E, Ortega Montes A, González RJ, Freita S, Alemparte E, Ortega A, María López A, Canabal J, Ferres E, Blanco Pérez J, Ortiz Piquer M, Freitas Ramos S, Lage Cendón L, Gómez Casal V, Vara Adrio S, Menor Fernández E, González Prado S, Varela Franco A, Luis Monzón J, Goñi F, Nogal Sáez FD, Blasco Navalpotro M, Díaz Abad R, Flordelis Lasierra JL, García-Torrejón MC, Pérez-Calvo C, López D, Arnaiz L, Sánchez-Alonso S, Velayos C, Del Río F, González MÁ, Nieto M, Sánchez Cesteros C, Cruz Martín M, Mª Molina J, Montejo JC, Catalán M, Albert P, de Pablo A, Eugenio Guerrero J, Zurita M, Benitez Peyrat J, Díaz Cámara M, Cerdá E, Alvarez M, Pey C, Manteiga Riestra E, Martinez-Fidalgo C, Rodríguez M, Palencia E, Caballero R, Vaquero C, Mariscal F, García S, Cepeda R, Carrasco N, Prieto I, Liétor A, Ramos R, Cuadra Casas R, Soriano Cuesta C, Sánchez Alonso S, Galván B, Figueira JC, Cruz Soriano M, Civantos Martín B, Robles Caballero A, Galdós P, Balandin Moreno B, Alcántara Carmona S, Del Cabo F, Hermosa C, Gordo F, Algora A, Paredes A, Grau Carmona T, Cambroner JA, López Ramos E, Ortiz de Zárate Y, Gómez-Rosado S, Mas Lodo M, Franco Garrobo N, Álvarez Hernández S, Honrubia T, Prado López LM, Esteban A, Lorente JA, Nin N, Jaramillo Sotomayor C, Arnaiz L, Molero Silvero E, Fernández de la Reguera EM, de la Casa Monje RM, Martín Serrano F, Trasmonte Martínez MV, Martín Delgado MC, Martínez S, Felices Abad F, Cremades Navalon I, Vigil Velis M, Martínez M, Martínez Baño D, Andreu E, Manuel Butí S, Gil Rueda B, García F, Llamas Fernández N, Herrera Para L, Ortín Freire A, Nvarro Ruiz MR, Hernández Romero CR, Maraví-Poma E, Urra IJ, Macaya Redin L, Tellería A, Insansti J, Artesero Garcia N, Macaya L, Lobo Palanco J, González N, Marco P, Vidaur L, Salas E, Salaberría Udabe R, Santamaría B, Rodríguez T, Vergara JC, Iruretagoyena Amiano JR, Garrido Santos I, Manzano A, Castillo Arenal C, Olaechea PM, Martín Hernández H, Martín López A, San Miguel FF, Blanquer J, Carbonell N, Ferreres Franco J, Reig Valero R, Belenger A, Altaba S, Álvarez-Sánchez B, Canovas Robles J, Sánchez Francisco J, Ruiz Sánchez M, Alberto Picos S, Arrascaeta Llanes A, Herrero Gutiérrez E, Fernández Zapata A, Sánchez-Miralles Á, Antón Pascual JL, Bonastre J, Palamo M, Cebrian J, Cuñat J, Gordón Sahuquillo M, Romero B, Borrás Pallé S, de León Belmar J, Zaragoza R, Tormo C, Sancho Chinesta S, Paricio V, Marques A, Sánchez-Morcillo S, Tormo S, Latour J, García MÁ, Palomo M, Tarín Royo F, Manzano Hinojosa P, Sánchez Pino MS, Maragues Ribes C, González Luis R, Ribas A.

Author information

1
Critical Care Department, Hospital Universitari de Tarragona Joan XXIII/IISPV/URV/CIBERes, Tarragona, Spain. ahr1161@yahoo.es.
2
Critical Care Department, Hospital Universitari de Tarragona Joan XXIII/IISPV/URV/CIBERes, Tarragona, Spain.
3
Multidisciplinary Intensive Care Research Organization (MICRO), Department of Anaesthesia and Critical Care, St James's University Hospital, Trinity Centre for Health Sciences, Dublin, Ireland.
4
Critical Care Department, ParcTaulí Hospital/CIBERes, Sabadell, Spain.
5
Critical Care Department, Hospital del Mar, IMIM/UPF/CIBERes, Barcelona, Spain.
6
Critical Care Department, Hospital del Henares, Madrid, Spain.
7
Critical Care Department, Hospital Dr Negrín, Las Palmas de Gran Canaria, Spain.
8
Otorhinolaryngology Head-Neck Surgery Department, Hospital Universitari de Tarragona Joan XXIII, IISPV/URV, Tarragona, Catalonia, Spain.
9
Division of Pulmonary Diseases and Critical Care Medicine University of Texas Health Science Center at San Antonio and South Texas Veterans Health Care System, San Antonio, Texas.
10
Critical Care Department, Hospital de Mataró, Mataró, Spain.
11
Critical Care Department, Hospital de Getafe, CIBERes, Madrid, Spain.
12
School of Medicine and Surgery University of Milan Bicocca San Gerardo Hospital, Monza, Italy.

Abstract

BACKGROUND:

Despite wide use of noninvasive ventilation (NIV) in several clinical settings, the beneficial effects of NIV in patients with hypoxemic acute respiratory failure (ARF) due to influenza infection remain controversial. The aim of this study was to identify the profile of patients with risk factors for NIV failure using chi-square automatic interaction detection (CHAID) analysis and to determine whether NIV failure is associated with ICU mortality.

METHODS:

This work was a secondary analysis from prospective and observational multi-center analysis in critically ill subjects admitted to the ICU with ARF due to influenza infection requiring mechanical ventilation. Three groups of subjects were compared: (1) subjects who received NIV immediately after ICU admission for ARF and then failed (NIV failure group); (2) subjects who received NIV immediately after ICU admission for ARF and then succeeded (NIV success group); and (3) subjects who received invasive mechanical ventilation immediately after ICU admission for ARF (invasive mechanical ventilation group). Profiles of subjects with risk factors for NIV failure were obtained using CHAID analysis.

RESULTS:

Of 1,898 subjects, 806 underwent NIV, and 56.8% of them failed. Acute Physiology and Chronic Health Evaluation II (APACHE II) score, Sequential Organ Failure Assessment (SOFA) score, infiltrates in chest radiograph, and ICU mortality (38.4% vs 6.3%) were higher (P < .001) in the NIV failure than in the NIV success group. SOFA score was the variable most associated with NIV failure, and 2 cutoffs were determined. Subjects with SOFA ≥ 5 had a higher risk of NIV failure (odds ratio = 3.3, 95% CI 2.4-4.5). ICU mortality was higher in subjects with NIV failure (38.4%) compared with invasive mechanical ventilation subjects (31.3%, P = .018), and NIV failure was associated with increased ICU mortality (odds ratio = 11.4, 95% CI 6.5-20.1).

CONCLUSIONS:

An automatic and non-subjective algorithm based on CHAID decision-tree analysis can help to define the profile of patients with different risks of NIV failure, which might be a promising tool to assist in clinical decision making to avoid the possible complications associated with NIV failure.

KEYWORDS:

CHAID analysis; influenza infection; noninvasive ventilation; prognosis

PMID:
28698265
DOI:
10.4187/respcare.05481
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center