Format

Send to

Choose Destination
Expert Opin Pharmacother. 2017 Aug;18(12):1269-1277. doi: 10.1080/14656566.2017.1353079. Epub 2017 Jul 27.

Rifamycin SV MMX for the treatment of traveler's diarrhea.

Lin SW1,2,3, Lin CJ1,2, Yang JC4.

Author information

1
a Graduate Institute of Clinical Pharmacy, College of Medicine , National Taiwan University , Taipei , Taiwan.
2
b School of Pharmacy, College of Medicine , National Taiwan University , Taipei , Taiwan.
3
c Department of Pharmacy , National Taiwan University Hospital , Taipei , Taiwan.
4
d Department of Internal Medicine, Hospital and College of Medicine , National Taiwan University , Taipei , Taiwan.

Abstract

Rifamycin SV MMX®, a non-absorbable rifamycin antibiotic formulated using the multi-matrix system, was designed to exhibit its pharmacological action on the distal small intestine and colon. Its clinical efficacy and safety profile in the treatment of traveler's diarrhea were evaluated in several clinical studies. Areas covered: This review summarizes all available evidence regarding clinical trials of the efficacy and safety profile of rifamycin SV MMX for the treatment of traveler's diarrhea. Expert opinion: Rifamycin SV MMX demonstrated an excellent pharmacokinetic profile with decreased systemic toxicity similar to rifaximin. In phase II and phase III clinical trials, concerns have been raised regarding the medicine's efficacy in terms of the time to last unformed stool and cure rate compared to current recommended antibiotics in the treatment of acute diarrhea caused by diarrheagenic Escherichia coli and invasive pathogens. The significance of the increase in MICs after the use of rifamycin SV MMX warrants further examination.

KEYWORDS:

Infectious diarrhea; non-absorbable antibiotics; rifamycin SV MMX; traveler’s diarrhea

PMID:
28697313
DOI:
10.1080/14656566.2017.1353079
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center