Format

Send to

Choose Destination
Pancreas. 2017 Aug;46(7):874-879. doi: 10.1097/MPA.0000000000000860.

Effect of Serum Triglycerides on Clinical Outcomes in Acute Pancreatitis: Findings From a Regional Integrated Health Care System.

Author information

1
From the *Department of Internal Medicine, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA; †Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA; ‡Division of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, PA; §Center for Basic and Translational Pancreatic Research, Cedars-Sinai Medical Center, Los Angeles, CA; ∥Global HEOR and Epidemiology, Shire, Lexington, MA; ¶Clinical Research and Development, Shire, Lexington, MA; and #Center for Pancreatic Care, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA.

Abstract

OBJECTIVES:

The aim of this study was to evaluate the effect of serum triglycerides on the development of multiple or persistent organ failure in patients with acute pancreatitis.

METHODS:

A retrospective cohort study was conducted among patients hospitalized for acute pancreatitis between 2006 and 2013. Triglyceride levels measured before and within 72 hours of admission were compared. In addition, the effect of triglyceride levels on the development of multiple or persistent organ failure during hospitalization for acute pancreatitis was assessed.

RESULTS:

Among 2519 patients, 267 patients (10.6%) developed organ failure, of which 75 patients developed multiple system organ failure and 82 patients developed persistent organ failure. Triglyceride levels in patients who developed organ failure were initially much higher than in patients who did not develop organ failure, but by 72 hours into admission, approached levels of patients who did not develop organ failure. Approximately 8% of patients had triglyceride levels greater than 500 mg/dL, the majority of which had similarly high levels before admission.

CONCLUSIONS:

Increased triglyceride levels were associated with the development of multiple or persistent organ failure among patients hospitalized with acute pancreatitis. Patients with high triglyceride levels at the time of admission were likely to have high triglyceride levels before admission.

PMID:
28697126
DOI:
10.1097/MPA.0000000000000860
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wolters Kluwer Icon for PubMed Central
Loading ...
Support Center