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Nat Commun. 2017 Jul 11;8:16035. doi: 10.1038/ncomms16035.

Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection.

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Jiangsu Province Key Laboratory of Modern Pathogen Biology, Department of Pathogen Biology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu 210029, China.


The pattern recognition receptor (PRR) scavenger receptor class A (SR-A) has an important function in the pathogenesis of non-infectious diseases and in innate immune responses to pathogen infections. However, little is known about the role of SR-A in the host adaptive immune responses to pathogen infection. Here we show with mouse models of helminth Schistosoma japonicum infection and heat-inactivated Mycobacterium tuberculosis stimulation that SR-A is regulated by pathogens and suppresses IRF5 nuclear translocation by direct interaction. Reduced abundance of nuclear IRF5 shifts macrophage polarization from M1 towards M2, which subsequently switches T-helper responses from type 1 to type 2. Our study identifies a role for SR-A as an innate PRR in regulating adaptive immune responses.

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