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Open Forum Infect Dis. 2016 Dec 7;4(1):ofw253. doi: 10.1093/ofid/ofw253. eCollection 2017 Winter.

Hepatitis B Virus Incidence and Risk Factors Among Human Immunodeficiency Virus-1 Negative Men Who Have Sex With Men in Kenya.

Author information

1
KEMRI-Wellcome Trust Research Programme Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.
2
International AIDS Vaccine Initiative, New York, New York.
3
KAVI Institute of Clinical Research, University of Nairobi, Kenya.
4
College of Health Sciences, School of Medicine, University of Nairobi, Kenya.
5
University of California at San Francisco, Department of Epidemiology and Biostatistics.
6
University of Washington, Seattle.
7
Nuffield Department of Medicine, University of Oxford, Headington, United Kingdom.

Abstract

No data exist on hepatitis B virus (HBV) incidence among African men who have sex with men (MSM). We tested plasma samples archived between 2005 and 2014 for HBV core antibody or surface antigen seroconversion in a cohort of 312 initially human immunodeficiency virus (HIV)-1-negative MSM with no evidence of prior HBV infection. Hepatitis B virus incidence was 6.0/100 person-years (95% confidence interval [CI], 3.9-9.1). Hepatitis B virus acquisition was associated with being uncircumcised (adjusted incidence rate ratio [aIRR], 5.0; 95% CI, 1.5-16.8), recent HIV-1 acquisition (aIRR, 2.9; 95% CI, 1.1-7.7), rape (aIRR, 5.0; 95% CI, 1.2-20.4), and any tertiary education (aIRR, 3.2; 95% CI, 1.1-9.7). African MSM have a substantial risk of HBV acquisition and require vaccination urgently.

KEYWORDS:

HBV incidence; HIV-1 acquisition; Kenya; MSM.; circumcision

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