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Open Ophthalmol J. 2017 Jun 12;11:107-116. doi: 10.2174/1874364101711010107. eCollection 2017.

Moxifloxacin Concentration and Proteomic Analysis of Aqueous Humor in Human Uveitis Associated with Oral Moxifloxacin Therapy.

Author information

1
Department of Ophthalmology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
2
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
3
Jamaica Hospital Medical Center, Queens, New York, USA.
4
Research Integrity and Compliance Review Office, Colorado State University, Colorado, USA.
5
Massachusetts Eye Research and Surgery Institution, Cambridge, Massachusetts, USA.
6
Ocular Inflammation and Uveitis Foundation, Cambridge, Massachusetts, USA.
7
Harvard Medical School, Boston, Massachusetts, USA.

Abstract

PURPOSE:

The aim was to report the aqueous humor moxifloxacin concentration and proteome profile of an individual with bilateral uveitis-like syndrome with pigment dispersion.

METHODS:

Multiple reactions monitoring mass spectrometry quantified the aqueous concentration of moxifloxacin in the affected individual. Shotgun proteomic analysis performed via liquid chromatography tandem mass spectrometry (LC-MS/MS) defined the protein profile in the affected individual and unaffected control samples.

RESULTS:

Moxifloxacin was present at higher than expected levels in aqueous humor 18 days following oral administration. One-third of the proteins were identified by significantly lower spectral counts in the aqueous of the individual with moxifloxacin associated uveitis compared to the unaffected control.

CONCLUSION:

Moxifloxacin was detected in aqueous humor 18 days following the completion of oral administration. These results suggest that moxifloxacin toxicity may be responsible for the uveitis-like syndrome with pigment dispersion syndrome induced by moxifloxacin therapy.

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