Format

Send to

Choose Destination
Ann Fam Med. 2017 Jul;15(4):355-358. doi: 10.1370/afm.2098.

Mortality Associated With Time in and Out of Buprenorphine Treatment in French Office-Based General Practice: A 7-Year Cohort Study.

Author information

1
Département Universitaire de Médecine Générale, Université Toulouse III Paul Sabatier, Toulouse, France julie.dupouy@dumg-toulouse.fr.
2
Inserm UMR1027, Université Toulouse III Paul Sabatier; Faculté de Médecine, Toulouse, France.
3
CEIP-Addictovigilance, CIC 1436, Service de Pharmacologie Médicale et Clinique, Faculté de Médecine, Toulouse, France.
4
Pôle Addictologie, CH Charles Perrens et CHU de Bordeaux, Bordeaux Cedex, France.
5
SANPSY (Addiction Psychiatry Team), CNRS USR 3413, Université de Bordeaux, PAC Carreire, Bordeaux Cedex, France.
6
CEIP-Addictovigilance Paca Corse, Service de Pharmacologie Clinique & Pharmacovigilance, Aix Marseille Université, Marseille, France.
7
Institut de Neurosciences Timone, CNRS 7289, secteur PIICI, Marseille, France.
8
Département Universitaire de Médecine Générale, Université Toulouse III Paul Sabatier, Toulouse, France.

Abstract

In France, most cases of opioid use disorder are treated with buprenorphine by general practitioners in private practice. Using reimbursement data of a representative sample of the French population, Echantillon Généraliste des Bénéficiaires, we investigated mortality during periods when patients were in and out of treatment in a cohort of 713 new users of buprenorphine having a mean (SD) follow-up of 4.5 (1.5) years. The mortality rate was 0.63 per 100 person-years (95% CI, 0.40-0.85) overall. In a multivariate Cox regression model, compared with being in treatment, being out of treatment was associated with a markedly increased risk of death (hazard ratio = 29.04; 95% CI, 10.04-83.99). Buprenorphine appears to be a strong protective factor against mortality.

KEYWORDS:

ambulatory care; buprenorphine; cohort studies; mortality; opioid maintenance treatment; opioid-related disorders; primary care; private practice

PMID:
28694272
PMCID:
PMC5505455
DOI:
10.1370/afm.2098
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center