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Elife. 2017 Jul 11;6. pii: e26635. doi: 10.7554/eLife.26635.

Type XVII collagen coordinates proliferation in the interfollicular epidermis.

Author information

1
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
2
Center for Simulation Sciences, Ochanomizu University, Tokyo, Japan.
3
Centre for Stem Cells and Regenerative Medicine, King's College London, London, United Kingdom.
4
Department of Life Sciences and Systems Biology, University of Turin, Turin, Italy.
5
Department of Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
6
Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
7
Department of Dermatology, Ehime University Graduate School of Medicine, Toon, Japan.
8
Department of Biological Response and Regulation, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
9
Research Institute for Electronic Science, Hokkaido University, Sapporo, Japan.

Abstract

Type XVII collagen (COL17) is a transmembrane protein located at the epidermal basement membrane zone. COL17 deficiency results in premature hair aging phenotypes and in junctional epidermolysis bullosa. Here, we show that COL17 plays a central role in regulating interfollicular epidermis (IFE) proliferation. Loss of COL17 leads to transient IFE hypertrophy in neonatal mice owing to aberrant Wnt signaling. The replenishment of COL17 in the neonatal epidermis of COL17-null mice reverses the proliferative IFE phenotype and the altered Wnt signaling. Physical aging abolishes membranous COL17 in IFE basal cells because of inactive atypical protein kinase C signaling and also induces epidermal hyperproliferation. The overexpression of human COL17 in aged mouse epidermis suppresses IFE hypertrophy. These findings demonstrate that COL17 governs IFE proliferation of neonatal and aged skin in distinct ways. Our study indicates that COL17 could be an important target of anti-aging strategies in the skin.

KEYWORDS:

developmental biology; epidermis; extracellular matrix; human; human biology; medicine; mouse; stem cells; tissue homeostasis

PMID:
28693719
PMCID:
PMC5505703
DOI:
10.7554/eLife.26635
[Indexed for MEDLINE]
Free PMC Article

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