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J Vet Sci. 2018 Jan 31;19(1):157-160. doi: 10.4142/jvs.2018.19.1.157.

Prepubertal growth and single nucleotide polymorphism analysis of the growth hormone gene of low birth weight Holstein calves.

Author information

1
Department of Farm Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
2
University Animal Farm, College of Agriculture & Life Sciences, Seoul National University, Pyeongchang 25354, Korea.
3
Dairy Cattle Improvement Center, National Agricultural Cooperative Federation, Goyang 10292, Korea.
4
Hyun-ri Animal Clinic, Gapyeong 12437, Korea.
5
Department of Biotechnology and Genomic Informatics Center, College of Agriculture & Life Science, Hankyong National University, Anseong 17579, Korea.
6
Farm Animal Clinical Training and Research Center, Institute of Green-Bio Science and Technology, Seoul National University, Pyeongchang 25354, Korea.

Abstract

Holstein calves weighing less than 20 kg at birth have been noted in Korea. Due to insufficient information, we raised small calves with age-matched normal birth weight Holstein calves and determined body weights before puberty. In addition, 3 single nucleotide polymorphisms (SNPs) of the growth hormone (GH) gene were analyzed. Up to 10 months of age, low birth weight calves were smaller than normal weight calves. In exon 5 of the GH gene, SNP genotype variation was detected in some small calves; however, this did not appear to be the only factor inducing low birth weight and slow growth.

KEYWORDS:

Holstein calf; growth hormone; low birth weight; prepubertal growth; single nucleotide polymorphism

PMID:
28693304
PMCID:
PMC5799394
DOI:
10.4142/jvs.2018.19.1.157
[Indexed for MEDLINE]
Free PMC Article

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