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J Vet Sci. 2018 Jan 31;19(1):137-142. doi: 10.4142/jvs.2018.19.1.137.

Magnetic resonance imaging characteristics of ischemic brain infarction over time in a canine stroke model.

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Ian Animal Diagnostic Center, Seoul 06014, Korea.
College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea.
Royal Animal Medical Center, Seoul 02117, Korea.
College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea.


This study describes magnetic resonance imaging (MRI) results and changes in lateral ventricular size over time in a canine ischemic stroke model. T1- and T2-weighted (T1W, T2W) imaging and fluid-attenuated inversion recovery (FLAIR) sequence MRI were performed at 3 h and 3, 8, and 35 days after brain infarct induction. Diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) mapping were performed at 8 and 35 days. A total of 29 brain lesions were induced successfully in 12 of 14 beagle dogs. At 3 h, T2W and FLAIR detected hyperintense lesions in three randomly selected dogs. On T1W, all lesions appeared hypointense to isointense at 3 h, isointense (18/29) or hypointense (11/29) at 3 days, hypointense to isointense with peripheral hyperintensity (24/26) at 8 days, and hypointense (18/26) at 35 days. Infarcts on DWI/ADC were hypointense to isointense centrally, with the periphery hyperintense/hyperintense (17/26) at 8 days and hypointense/hyperintense (19/26) at 35 days. A marked increase in lateral ventricular size was observed in dogs with cerebral infarcts. In conclusion, T2W and FLAIR were useful for detecting early stage (3 h to 3 days) brain infarction. T1W and DWI were useful for detecting neuronal necrosis and providing supplemental information for phase evaluation.


brain infarction; dogs; lateral ventricles; magnetic resonance imaging; time passage

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