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J Vet Sci. 2018 Jan 31;19(1):137-142. doi: 10.4142/jvs.2018.19.1.137.

Magnetic resonance imaging characteristics of ischemic brain infarction over time in a canine stroke model.

Author information

1
Ian Animal Diagnostic Center, Seoul 06014, Korea.
2
College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea.
3
Royal Animal Medical Center, Seoul 02117, Korea.
4
College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea.

Abstract

This study describes magnetic resonance imaging (MRI) results and changes in lateral ventricular size over time in a canine ischemic stroke model. T1- and T2-weighted (T1W, T2W) imaging and fluid-attenuated inversion recovery (FLAIR) sequence MRI were performed at 3 h and 3, 8, and 35 days after brain infarct induction. Diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) mapping were performed at 8 and 35 days. A total of 29 brain lesions were induced successfully in 12 of 14 beagle dogs. At 3 h, T2W and FLAIR detected hyperintense lesions in three randomly selected dogs. On T1W, all lesions appeared hypointense to isointense at 3 h, isointense (18/29) or hypointense (11/29) at 3 days, hypointense to isointense with peripheral hyperintensity (24/26) at 8 days, and hypointense (18/26) at 35 days. Infarcts on DWI/ADC were hypointense to isointense centrally, with the periphery hyperintense/hyperintense (17/26) at 8 days and hypointense/hyperintense (19/26) at 35 days. A marked increase in lateral ventricular size was observed in dogs with cerebral infarcts. In conclusion, T2W and FLAIR were useful for detecting early stage (3 h to 3 days) brain infarction. T1W and DWI were useful for detecting neuronal necrosis and providing supplemental information for phase evaluation.

KEYWORDS:

brain infarction; dogs; lateral ventricles; magnetic resonance imaging; time passage

PMID:
28693299
PMCID:
PMC5799391
DOI:
10.4142/jvs.2018.19.1.137
[Indexed for MEDLINE]
Free PMC Article

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