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Sci Total Environ. 2017 Dec 15;605-606:1003-1010. doi: 10.1016/j.scitotenv.2017.06.151. Epub 2017 Jul 12.

Path analysis of prenatal mercury levels and birth weights in Korean and Taiwanese birth cohorts.

Author information

1
Division of Cancer Prevention, National Cancer Control Institute, National Cancer Center, Goyang, Republic of Korea.
2
Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan; Department of Pediatrics, National Taiwan University Hospital Yun-Lin Branch, Yunlin County, Taiwan; Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan.
3
Occupational Health Section, Environmental Protection Center, National Taiwan University, Taiwan.
4
Department of Preventive Medicine, School of Medicine, Ewha Medical Research Center, Ewha Womans University, Seoul, Republic of Korea.
5
Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea.
6
Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.
7
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
8
Department of Obstetrics Medicine, School of Medicine, Ewha Medical Research Center, Ewha Womans University, Seoul, Republic of Korea.
9
Department of Preventive Medicine, School of Medicine, Ewha Medical Research Center, Ewha Womans University, Seoul, Republic of Korea. Electronic address: eunheeha@ewha.ac.kr.

Abstract

Prospective cohort studies of the effect of mercury (Hg) exposure on birth weight have shown conflicting results. We combined data from Taiwanese and Korean birth cohorts, and assessed the effects of Hg exposure on birth weight. The first cohort was drawn from the Mothers and Children's Environmental Health (MOCEH) study performed in Korea from 2006 to 2010. The second cohort was enrolled from 2004 to 2005 and included singleton term births from the Taiwan Birth Panel Study (TBPS). In total, 1147 pregnant women were included in this study. A pooled analysis was performed to obtain combined estimates of the association between prenatal total Hg exposure and birth weight. A significant negative association between maternal and cord blood Hg and birth weight in the high-Hg group (Hg level>25th percentile) was detected (maternal blood: β=-0.056; 95% CI, -0.100 to -0.013, cord blood: β=-0.075; 95% CI, -0.121 to -0.028). Hg level showed a negative coefficient in the path analysis, indicating an adverse effect on birth weight (total effects: β=-0.177, P=0.01 in MOCEH, β=-0.204, P=0.03 in TBPS), but fish consumption exhibited a strong positive coefficient. In addition, fish consumption exerted a significant indirect effect on birth weight through exposure to cord blood Hg. Exposure to hazardous contaminants and beneficial nutrients may be highly correlated in those who frequently consume fish. Moreover, Hg in cord blood may adversely affect birth weight.

KEYWORDS:

Birth weight; Cohort; Korea; Mercury; Prenatal exposure; Taiwan

PMID:
28693105
DOI:
10.1016/j.scitotenv.2017.06.151
[Indexed for MEDLINE]

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