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J Acquir Immune Defic Syndr. 2017 Aug 15;75(5):588-596. doi: 10.1097/QAI.0000000000001449.

Δ9-Tetrahydrocannabinol Suppresses Secretion of IFNα by Plasmacytoid Dendritic Cells From Healthy and HIV-Infected Individuals.

Author information

1
*Michigan State University East Lansing, MI; †Department of Pharmacology and Toxicology East Lansing, MI; ‡Institute for Integrative Toxicology East Lansing, MI; §Department of Cell and Molecular Biology East Lansing, MI; and ‖Department of Osteopathic Medicine East Lansing, MI.

Abstract

Plasmacytoid dendritic cells (pDCs) play a crucial role in host antiviral immune response through secretion of type I interferon. Interferon alpha (IFNα), a type I IFN, is critical for mounting the initial response to viral pathogens. A consequence of Human Immunodeficiency Virus-1 (HIV) infection is a decrease in both pDC number and function, but prolonged pDC activity has been linked with progression from HIV infection to the development of AIDS. Patients with HIV in the United States routinely use cannabinoid-based therapies to combat the side effects of HIV infection and antiretroviral therapy. However, cannabinoids, including Δ-tetrahydrocannabinol (THC), are well-characterized immunosuppressants. Here, we report that THC suppressed secretion of IFNα by pDC from both healthy and HIV+ donors through a mechanism involving impaired phosphorylation of interferon regulatory factor 7. These results suggest that THC can suppress pDC function during the early host antiviral response by dampening pDC activation.

PMID:
28692581
PMCID:
PMC5527743
DOI:
10.1097/QAI.0000000000001449
[Indexed for MEDLINE]
Free PMC Article

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