Format

Send to

Choose Destination
Dev Neurorehabil. 2018 Oct;21(7):423-430. doi: 10.1080/17518423.2017.1338777. Epub 2017 Jul 10.

Preliminary findings of altered functional connectivity of the default mode network linked to functional outcomes one year after pediatric traumatic brain injury.

Author information

1
a Kennedy Krieger Institute , Johns Hopkins School of Medicine , Baltimore , MD , USA.
2
b Department of Physical Medicine and Rehabilitation , Johns Hopkins School of Medicine , Baltimore , MD , USA.
3
c Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research , Manhasset, NY, USA.
4
d Department of Pediatric Neurology , Baylor College of Medicine , Texas Children's Hospital, Houston TX , USA.
5
e Department of Pediatrics , Johns Hopkins School of Medicine , Baltimore , MD , USA.
6
f Department of Neurology , Johns Hopkins School of Medicine , Baltimore , MD , USA.

Abstract

PURPOSE AND METHOD:

This study examined functional connectivity of the default mode network (DMN) and examined brain-behavior relationships in a pilot cohort of children with chronic mild to moderate traumatic brain injury (TBI).

RESULTS:

Compared to uninjured peers, children with TBI demonstrated less anti-correlated functional connectivity between DMN and right Brodmann Area 40 (BA 40). In children with TBI, more anomalous less anti-correlated) connectivity between DMN and right BA 40 was linked to poorer performance on response inhibition tasks.

CONCLUSION:

Collectively, these preliminary findings suggest that functional connectivity between DMN and BA 40 may relate to longterm functional outcomes in chronic pediatric TBI.

KEYWORDS:

Functional neuroimaging; mild traumatic brain injury; moderate traumatic brain injury; neural networks; response inhibition

PMID:
28692408
PMCID:
PMC5843556
DOI:
10.1080/17518423.2017.1338777
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center