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Mol Inform. 2017 Oct;36(10). doi: 10.1002/minf.201700048. Epub 2017 Jul 10.

Network-based Approaches in Pharmacology.

Author information

1
Université Paris Diderot - Inserm UMR-S973, MTi, 75205, Paris Cedex 13, 75013, Paris, France.
2
Institut de Recherche Servier, 125 Chemin de Ronde, 78290, Croissy-sur-Seine, France.

Abstract

In drug discovery, network-based approaches are expected to spotlight our understanding of drug action across multiple layers of information. On one hand, network pharmacology considers the drug response in the context of a cellular or phenotypic network. On the other hand, a chemical-based network is a promising alternative for characterizing the chemical space. Both can provide complementary support for the development of rational drug design and better knowledge of the mechanisms underlying the multiple actions of drugs. Recent progress in both concepts is discussed here. In addition, a network-based approach using drug-target-therapy data is introduced as an example.

KEYWORDS:

Systems Pharmacology; biological network; chemical space network; drug-target; drug-therapy

PMID:
28692140
DOI:
10.1002/minf.201700048
[Indexed for MEDLINE]

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