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Nat Neurosci. 2017 Sep;20(9):1277-1284. doi: 10.1038/nn.4601. Epub 2017 Jul 10.

Neural reactivations during sleep determine network credit assignment.

Gulati T1,2,3, Guo L1,2,3, Ramanathan DS1,3,4,5, Bodepudi A1,2, Ganguly K1,2,3.

Author information

1
Neurology and Rehabilitation Service, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA.
2
Department of Neurology, University of California-San Francisco, San Francisco, California, USA.
3
Center for Neural Engineering and Prostheses, University of California-Berkeley and University of California-San Francisco, California, USA.
4
Department of Psychiatry, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA.
5
Department of Psychiatry, University of California-San Francisco, San Francisco, California, USA.

Abstract

A fundamental goal of motor learning is to establish the neural patterns that produce a desired behavioral outcome. It remains unclear how and when the nervous system solves this 'credit assignment' problem. Using neuroprosthetic learning, in which we could control the causal relationship between neurons and behavior, we found that sleep-dependent processing was required for credit assignment and the establishment of task-related functional connectivity reflecting the casual neuron-behavior relationship. Notably, we observed a strong link between the microstructure of sleep reactivations and credit assignment, with downscaling of non-causal activity. Decoupling of spiking to slow oscillations using optogenetic methods eliminated rescaling. Thus, our results suggest that coordinated firing during sleep is essential for establishing sparse activation patterns that reflect the causal neuron-behavior relationship.

PMID:
28692062
PMCID:
PMC5808917
DOI:
10.1038/nn.4601
[Indexed for MEDLINE]
Free PMC Article

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