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Int J Gynaecol Obstet. 2017 Jul;138 Suppl 1:15-19. doi: 10.1002/ijgo.12187.

Optimizing secondary prevention of cervical cancer: Recent advances and future challenges.

Author information

1
School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
2
BC Women's Hospital and Health Centre, Vancouver, BC, Canada.
3
Department of Gyncologic Oncology, Uganda Cancer Institute, Kampala, Uganda.
4
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL, USA.
5
Department of Clinical Oncology, National Institute of Cancer Prevention and Research, Noida, India.
6
Departments of Oncology and Epidemiology & Biostatistics, McGill University, Montreal, Canada.
7
PATH, Seattle, WA, USA.

Abstract

Although human papillomavirus (HPV) vaccines offer enormous promise for the ultimate control and possible elimination of cervical cancer, barriers to uptake and coverage of the vaccine both in high- and low/middle-income settings mean that advances in secondary prevention continue to be essential to prevent unnecessary deaths and suffering from cervical cancer for decades to come. While cytology (the Pap smear) has reduced cervical cancer incidence and prevalence in jurisdictions where it has been systematically implemented in population-based programs-mainly in high-income settings-limitations inherent to this method, and to program delivery, leave many women still vulnerable to cervical cancer. Recent evidence has confirmed that screening based on HPV testing prevents more invasive cervical cancer and precancerous lesions, and offers innovative options such as self-collection of specimens to improve screening uptake broadly. In this paper, we review key advances, future opportunities, and ongoing challenges for secondary prevention of cervical cancer using HPV-based testing.

KEYWORDS:

HPV ; Cervical cancer; Eradication; Screening; Self-collection

PMID:
28691338
DOI:
10.1002/ijgo.12187
[Indexed for MEDLINE]

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