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ACS Cent Sci. 2017 Jun 28;3(6):647-653. doi: 10.1021/acscentsci.7b00159. Epub 2017 May 17.

A General Small-Scale Reactor To Enable Standardization and Acceleration of Photocatalytic Reactions.

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Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States.
Discovery Chemistry and Process Research & Development, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.


Photocatalysis for organic synthesis has experienced an exponential growth in the past 10 years. However, the variety of experimental procedures that have been reported to perform photon-based catalyst excitation has hampered the establishment of general protocols to convert visible light into chemical energy. To address this issue, we have designed an integrated photoreactor for enhanced photon capture and catalyst excitation. Moreover, the evaluation of this new reactor in eight photocatalytic transformations that are widely employed in medicinal chemistry settings has confirmed significant performance advantages of this optimized design while enabling a standardized protocol.

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