Format

Send to

Choose Destination
Eur J Cancer. 2017 Sep;82:137-148. doi: 10.1016/j.ejca.2017.05.028. Epub 2017 Jul 6.

Geographical variability in survival of European children with central nervous system tumours.

Collaborators (157)

Hackl M, Zielonke N, Oberaigner W, Van Eycken E, Henau K, Valerianova Z, Dimitrova N, Sekerija M, Storm H12, Engholm G12, Mägi M13, Aareleid T13, Malila N, Seppä K, Faivre J, Bossard N14, Uhry Z15, Colonna M, Clavel J, Lacour B, Desandes E, Brenner H16, Kaatsch P, Katalinic A, Garami M, Jakab Z, Comber H17, Mazzoleni G, Bulatko A, Buzzoni C18, Giacomin A, Sutera Sardo A, Mancuso P, Ferretti S, Barchielli A, Caldarella A, Gatta G19, Sant M19, Amash H19, Amati C19, Baili P19, Berrino F19, Bonfarnuzzo S19, Botta L19, Capocaccia R19, Di Salvo F19, Foschi R19, Margutti C19, Meneghini E19, Minicozzi P19, Trama A19, Serraino D20, Zucchetto A20, De Angelis R21, Caldora M21, Carrani E21, Francisci S21, Mallone S21, Pierannunzio D21, Roazzi P21, Rossi S21, Santaquilani M21, Tavilla A21, Pannozzo F, Busco S, Filiberti RA, Marani E, Ricci P, Pascucci C, Autelitano M, Spagnoli G, Cirilli C, Fusco M, Vitale MF, Usala M, Vitale F, Ravazzolo B, Michiara M, Merletti F, Maule M, Tumino R, Mangone L, Di Felice E, Falcini F, Iannelli A, Sechi O, Cesaraccio R, Piffer S22, Madeddu A, Tisano F, Maspero S, Fanetti AC, Candela P, Scuderi T, Stracci F, Bianconi F, Tagliabue G19, Contiero P19, Rugge M, Guzzinati S, Pildava S, Smailyte G, Calleja N23, Agius D23, Johannesen TB, Rachtan J, Góźdź S, Mężyk R, Błaszczyk J, Bębenek M, Bielska-Lasota M24, Forjaz de Lacerda G, Bento MJ, Castro C, Miranda A, Mayer-da-Silva A, Safaei Diba C, Primic-Zakelj M25, Errezola M, Bidaurrazaga J, Vicente Raneda M, Díaz García JM, Marcos-Navarro AI, Marcos-Gragera R, Izquierdo Font A, Sanchez MJ, Chang DYL, Navarro C, Chirlaque MD, Moreno-Iribas C, Ardanaz E, Peris-Bonet R26, Pardo Romaguera E26, Galceran J, Carulla M, Lambe M27, Mousavi M, Bouchardy C, Usel M, Ess SM, Frick H, Lorez M, Herrmann C, Bordoni A, Spitale A, Konzelmann I, Visser O, Aarts M, Otter R, Coleman M28, Allemani C28, Rachet B28, Verne J, Stiller C29, Gavin A, Donnelly C, Brewster DH.

Author information

1
Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Electronic address: gemma.gatta@istitutotumori.mi.it.
2
Spanish Registry of Childhood Tumours (RETI-SEHOP), Universidad de Valencia, Valencia, Spain. Electronic address: Rafael.Peris@uv.es.
3
Netherlands Comprehensive Cancer Organization, Utrecht, The Netherlands. Electronic address: O.Visser@iknl.nl.
4
National Cancer Registration and Analysis Service, Public Health England, Oxford, UK. Electronic address: charles.stiller@new.ox.ac.uk.
5
Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Government of Catalonia, Catalan Institute of Oncology, Girona, Spain. Electronic address: rmarcos@ico.scs.es.
6
Escuela Andalusa de Salud Pública, Instituto de Investigación Biosanitaria ibs, Granada, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. Electronic address: mariajose.sanchez.easp@juntadeandalucia.es.
7
French National Registry of Childhood Solid Tumours, CHU, Nancy, France; INSERM, UMRS-1153, CRESS Team 7, University of Paris-Sorbonne, Paris, France. Electronic address: brigitte.lacour@univ-lorraine.fr.
8
German Childhood Cancer Registry, Institute for Medical Biostatistics, Epidemiology and Informatics, University of Mainz, Mainz, Germany. Electronic address: peter.kaatsch@unimedizin-mainz.de.
9
Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Electronic address: franco.berrino@istitutotumori.mi.it.
10
Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, Germany. Electronic address: s.rutkowski@uke.de.
11
Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Electronic address: laura.botta@istitutotumori.mi.it.
12
Danish Cancer Society, Denmark.
13
National Institute for Health Development, Estonia.
14
Hospices Civils de Lyon, France.
15
Hospices Civils de Lyon, Institut de Veille Sanitaire, France.
16
German Cancer Research Center, Germany.
17
National Cancer Registry Ireland, Ireland.
18
Associazione Italiana Registri Tumoure, Italy.
19
Fondazione IRCCS Istituto Nazionale dei Tumouri, Milan, Italy.
20
CRO Aviano National Cancer Institute, Italy.
21
Istituto Superiore di Sanità, Rome, Italy.
22
Servizio Epidemiologia Clinica e Valutativa, Trento, Italy.
23
Malta National Cancer Registry, Health Information and Research, Malta.
24
National Institute of Public Health-NIH, Warszawa, Poland.
25
Cancer Registry of Republic of Slovenia, Slovenia.
26
Spanish Registry of Childhood Tumours, RETI-SEHOP, Spain.
27
Regionalt cancercentrum, Karolinska Institutet, Sweden.
28
London School of Hygiene and Tropical Medicine, UK.
29
Childhood Cancer Research Group, Oxford, UK.

Abstract

Survival for childhood central nervous system (CNS) tumours varies across Europe, partly because of the difficulty of distinguishing malignant from non-malignant disease. This study examines bias in CNS tumours survival analysis to obtain the reliable and comparable survival figures. We analysed survival data for about 15,000 children (age <15) diagnosed with CNS between 2000 and 2007, from 71 population-based cancer registries in 27 countries. We selected high-quality data based on registry-specific data quality indicators and recorded observed 1-year and 5-year survival by countries and CNS entity. We provided age-adjusted survival and used a Cox model to calculate the hazard ratios (HRs) of death, adjusting by age, site and grading by country. Recording of non-malignant lesions, use of appropriate morphology codes and completeness of life status follow-up differed among registries. Five-year survival by countries varied less when non-malignant tumours were included, with rates between 79.5% and 42.8%. The HRs of dying, for registries with good data, adjusting by age and grading, were between 0.7 and 1.2; differences were similar when site (supra- and infra-tentorial) was included. Several sources of bias affect the correct definition of CNS tumours, the completeness of incidence series and the goodness of follow-up. The European Network of Cancer Registries needs to improve childhood cancer registration and stress the need to update the International Classification for Cancer. Since survival differences persisted even when restricting the analysis to registries with satisfactory data, and since diagnosis of CNS tumours is difficult and treatment complex, national plans must aim for the revision of the diagnosis and the coordination of care, with adequate national and international networks.

KEYWORDS:

Central nervous system; Childhood cancer survival; Disparities; Europe; Population-based cancer registries

PMID:
28689091
DOI:
10.1016/j.ejca.2017.05.028
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center